Genetic: a predisposition to this problem may be present, and depressive diseases seem to run in families. Predisposing factors: Childhood traumas, car accidents, brain injuries, abuse and domestic violence, poor parenting, growing up in an alcoholic home, chemotherapy. Immediate factors: violent attack, illness, sudden loss or grief, loss of a relationship, any severe shock to the system. (Anderson, 1999,Quinnett, 2000) We do not yet know how genetic factors predispose people to depressive illnesses, but research suggests that heredity is definitely a factor. Predisposing factors are varied, but most seem to be the result of extreme stress, either acute, as in an illness, or chronic, as in domestic violence, sexual abuse of children, or poor parenting. Stress seems to have a powerful impact on the amygdala, the place in our brain where we respond to stress or danger. It also increases the agitation of the limbic system, and seems to damage cells in the hippocampus. Severe shocks to the system may or may not lead to depression, but predisposing factors and heredity, teamed with a severe shock, will almost certainly lead to depression. Youth Depression and Suicide.

Researchers have recognised the gene which has the central role in the reduction or amplification of stress, basing upon the activity level of this particular gene, an advancement which leads to the targeted therapies for the treatment of depression.

Depression, on a global scale, affects around 300 million individuals on an annual basis. Around 800,000 die due to suicide every year, making it the second leading reason of death among the global population ageing between 15 to 29 years of age, researchers added.

The research study which was published in the Journal of Neuroscience happens to be the first to elaborate the way this particular gene, named as Slc6a15, works in a type of neurone which plays an important role in causing depression. It identified the association in both humans and animals.

“This study illuminates in the manner this gene levels present in the neurones have effects on mood,” stated an assistant professor, Mary Kay Lobo, from the University of Maryland School of Medicine in the United States.

“It suggests that individuals with changed levels of this particular gene in specific regions of the brain may have a greater risk for emotional disorders including depression associated with stress,” stated Lobo.

Lobo and the research team also concentrated on a specific part of the brain known as the nucleus accumbens that has a very important and central role in the “reward circuit” in the brain.

When you consume delicious meals, drink alcohol, have sex,  or any such kind of pleasurable experience, neurones present in the nucleus accumbens are stimulated and activated, and signify you to know that the experience is stimulating proper buttons, experts added.

In depression, any enjoyment turns out impossible or difficult; this symptom is called as anhedonia that in Latin means the lack of ability to experience enjoyment.

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