People with high amount of phosphate in dietary intake are likely to suffer from heart diseases later in life, says a new study. Researchers from the University of Leicester found that high levels of phosphate in diet might trigger a stress signal in the cells surrounding the blood vessels that further instructs the brain to release microparticles resulting in blood clots in the body and these blood clots within the body makes one more susceptible to heart disease.
Researchers said that patients suffering from chronic kidney disease (CKD) are unable to excrete the excess the phosphate present in the body through urine. This excess phosphate then gets accumulated in the blood cells which play a key role in causing heart diseases, especially in patients with CKD.
Since phosphate is easily found in a normal diet, even healthy people can become the victim of hyperphosphatemia. They study revealed the mechanism by which excess inorganic phosphate triggers a stress signal inside the body cells. The stress level was similar to the levels found in CKD patients. These stressed cells break off into fragments and promotes the formation of blood clots, triggering cardiovascular diseases.
Lead researcher of the study published the Journal of the American Society of Nephrology (JASN), Alan Bevington said that this is important because blocking of blood vessels by blood clots, a process known as thrombosis, is a common cause of injury and death, occurring in a wide range of human illnesses including CKD.
The results of the study are mostly related to patients with kidney dysfunction. However, it warned the people with normal kidney function. Moreover, excessive phosphate causes other metabolic imbalances in the body apart from cardiovascular diseases. Thus, the study might give new insight towards other health complications.