Statin that controls cholesterol, ups diabetes and obesity risk

In a new finding, researchers have revealed that statin, a drug used to lower cholesterol level can significantly increase the new-onset diabetes even in the healthy group of people. According to the researchers, people who consume statin to control cholestrol level are 87 percent more likely to develop diabetes in future when compared to their non-statin counterpart.

The study was based on nearly 26,000 beneficiaries of Tricare, the military health system. All the participants were healthy and were free from heart disease, diabetes and other chronic diseases. Some participants were fed with statins on a regular basis. After analyzing their data researchers found that people who consumed statin were 87 percent more likely to develop new-onset diabetes. Apart from this, statin consumers were also 14 percent more likely to become obese in near future when compared to people who didn’t consume the drug.

Lead author Ishak Mansi of University of Texas Southwestern said that the diabetes risk with statin consumption was known earlier, but scientists didn’t know exactly to what extent it affects people. In the study it was found that higher the dose, higher risk of diabetes and obesity.

While explaining, Mansi said that stain controls cholestrol levels by inhibiting the enzyme HMG-CoA reductase, which plays a central role in the production of cholesterol in the liver, which produces about 70 percent of total cholesterol in the body.

Moreover, he suggested not to stop the intake of statin.”No patient should stop taking their statins based on our study, since statin therapy is a cornerstone in treatment of cardiovascular diseases and has been clearly shown to lower mortality and disease progression,” he says. “Rather, this study should alert researchers, clinical guideline writers, and policymakers that short-term clinical trials might not fully describe the risks and benefits of long-term statin use for primary prevention.”

The study appeared in the Journal of General Internal Medicine.

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