Obese? Reduce sedentary behaviour to cut short risk of heart disease

Are you suffering from obesity? If yes, then here’s another research that will make you think twice for losing weight as researchers have warned that obesity can lead to permanent DNA changes which can adversely affect your health. What’s even more surprising is that alteration in DNA also can have adverse health consequences on your future children.

Scientists wanted to find a correlation between Body Mass Index (BMI) and epigenetic changes that tell us how our behaviour and surroundings inject new traits by changing our DNA which are also passed on to next generation.

“Our results allow new insights into which signaling pathways are influenced by obesity”, said Christian Gieger, a researcher involved in the study, in a recent statement. “We hope that this will lead to new strategies for predicting and possibly preventing type 2 diabetes and other consequences of being overweight.”

For the study, researchers observed over 10,000 men and women from Europe. Most of the participants were obese or were at high risk of obesity and metabolic disease. Study authors collected blood samples of all the participants and tracked the gene markers. They identified 207 gene loci in 5,387 samples that were epigenetically altered dependent on the BMI. They then tested these candidate loci in blood samples of an additional 4,874 subjects and were able to confirm 187 of these.

With the study, researchers were able to prove that obesity can have long lasting effect on DNA. These epigenetic changes also pass on to future generation and affect health of your offsprings.

According to estimates, over half a billion people in the world are suffering from obesity and the numbers are increasing exponentially. Study authors blame modern lifestyle and use of junk food for the disease. Obesity also increases the risk of several other diseases including cardiovascular disease and pulmonary diseases. Thus, study authors warned people to curb weight and fight obesity in order to keep offsprings healthy.

The study appeared in the journal Nature.

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