Decoded: Why some find it hard to lose weight, protein to be blamed

Finally, researchers have explained why it is very hard for some people to lose weight even after hours of workout while some lose weight in a jiffy. According to researchers, the body of fatter people produces a protein which obstructs fat burning in the body and the fatter we are the more protein is produced by the body that further inhibits burning of fat which eventually results in making us more fat. Thus, it is a chain process which once started is really very hard to break.

While explaining the functioning of the fat cells, study authors said that nearly all the fat cells store energy in the body and they release it when needed or at the time of crisis. However, some fat cells are also used for generating heat in the body like brown adipocyte which keeps our body warm through a process called thermogenesis. Researchers have found that a protein named sLR11 inhibits this process of thermogenesis thus, it becomes hard to burn fat for some.

While the conducting the study over mice, researchers from the Wellcome Trust-Medical Research Council Institute of Metabolic Sciences at the University of Cambridge, UK, and Toho University, Japan, found that mice without sLR11 lost weight easily and showed resistance towards weight gain. Researchers explained that when we move from lower calorie diet to higher calorie diet, our metabolic rate increases but mice lacking the gene to produce sLR11 responded to the change very well that suggests they burned calories at a faster rate.

Co-study author Andrew Whittle said that sLR11 prevents the body from burning fat to generate heat and to cover up short term drop in temperature like we witness just after large meals. This enables adipose tissue to store fat for a longer period of time and makes it hard for people to lose weight even after spending several hours in the gym.

Whittle further added that the study has given a better insight into why it is very hard for some people to lose weight. Moreover, the research paves the way for new studies at molecular level in fighting the stored fat.

The study appeared in the journal Nature Communication.

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