Alzheimer drug stimulates stem cells in tooth
All this drug does is stops GSK-3, which is an enzyme that prevents the formation of dentine. Dentine is the mineralised material under the enamel of a tooth, once this is allowed to form, the process of boosting living stem cells starts and the injury site is filled naturally.

Researchers from Dental Institute at King’s College London in a newly published paper tells how Tideglusib, the drug used for Alzheimer’s patients can replace fillings used in a tooth when it gets affected due to infection. It won’t only replace the fillings such as calcium, other sulphur products, and cement but will also help the tooth to repair itself.

Tideglusib’s advantage over other methods is so much that it almost gives back the old tooth whereas the other ways that are normally used by dentists need the tooth to be extracted after being filled again and again. All this drug does is stops GSK-3, which is an enzyme that prevents the formation of dentine. Dentine is the mineralised material under the enamel of a tooth, once this is allowed to form, the process of boosting living stem cells starts and the injury site is filled naturally.

Paul Sharpe, a researcher at King’s College London and an author of the paper said “The simplicity of our approach makes it ideal as a clinical dental product for the natural treatment of large cavities, by providing both pulp protection and restoring dentine. In addition, using a drug that has already been tested in clinical trials for Alzheimer’s disease provides a real opportunity to get this dental treatment quickly into clinics.”

The team has experimented on a mouse, in which they applied collagen sponges and saw the renewal of living stem cells. The scientists would also like to experiment the same and see the results for different organs. According to them, this natural repairing method will be opted by dentists, everywhere and will mark a huge leap. It will also provide ease to the people who have dental phobia.

The paper was published under the title of ‘Promotion of natural tooth repair by small molecule GSK3 antagonists’ in Scientific Reports on Monday.

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